【摘要】 目的:探讨β受体阻滞剂比索洛尔治疗慢性心力衰竭时对外周血中血浆肾素活性(PRA)、脑钠肽(BNP)及左心室功能的影响。方法:97例慢性心衰患者随机分为对照组(血管紧张素转换酶抑制剂+利尿剂+地高辛)和治疗组(常规治疗药物+比索洛尔),治疗24周,测定治疗前后2组外周血中PRA及BNP水平。同时比较2组患者左心室射血分数(LVEF)和左室舒张末内径(LVEDD)的改变。结果:两组患者治疗后外周血中PRA、BNP水平较治疗前显著降低(P<0.05),治疗组外周血中PRA、BNP水平较常规治疗组下降更明显(P<0.05)。治疗组LVEF和LVEDD明显改善(P<0.05)。结论:比索洛尔能抑制慢性心衰患者神经内分泌的过度激活,改善患者左心室功能。更多还原

【Abstract】 Objective: To investigate the effects of bisoprolol on plasma renin activity,brain natriuretic peptide and left ventricular function in patients with chronic heart failure.Methods:97 patients were randomly divided into treatment group(n=50) and control group(n=47).The patients of control group were treated with routine drugs(digitalis,diuretics and ACEI) and those of treatment group were treated with bisoprolol additionally.Plasma renin activity(PRA),brain natriuretic peptides(BNP),left ventricular ejective fraction(LVEF) and left ventricular diastolic diameter(LVEDD) were measured before and 24 weeks’ after treatment.Results:The levels of PRA and BNP decreased after treatment.Those of treatment group were lower than the control group.LVEFs of patients with bisoprolol treatment increased and LVDDs decreased.Conclusion:Bisoprolol can suppress neurohumoral over activation in patients with CHF.It can significantly improve left ventricular function.更多还原