【摘要】 目的检测CD99在胰腺内分泌肿瘤(pancreatic endocrine tumors,PETs)中的表达并分析CD99与PETs临床病理学特征之间的关系。方法对34例PETs进行CD99免疫组化染色并分析其与临床病理学特征的关系。结果 34例PETs中1,8例(53%)CD99阳性,5例有局部浸润(其中两例有淋巴结转移),均显示CD99阴性;1例发生脾脏和肝脏转移,CD99阳性细胞数<30%。PETs中CD99的表达与局部浸润、肿瘤转移及组织学分级相关,CD99表达与肿瘤大小和功能状态无相关性。随访结果分析显示,CD99表达缺失或低表达可能预示PETs预后不良。结论 CD99表达与PETs生物学行为密切相关,提示CD99表达缺失或低表达与PETs的恶性进展及不良预后相关,CD99可以作为PETs独立的预后指标。更多还原

【Abstract】 Purpose To examine the expression of CD99 in pancreatic endocrine tumors(PETs) and to analyze the correlation with clinicopathologic parameters.Methods Analyses of 34 PETs was undertaken to perform immunohistochemical staining with CD99 and to evaluate the correlation with clinicopathologic features.Results Of the 34 PETs,18 cases(53%) were CD99-positive,5 cases with local invasion(including the 2 lymph node involvement) were all CD99-negative;1 with spleen and liver metastases showed less than 30% of the tumor population being CD99-positive.The expression of CD99 was significantly correlated with gross local invasion,metastasis to the lymph nodes or other organs,and histological grade.However,tumor size and functional status showed no significant association with CD99 expression.The follow-up results showed that loss/low expression of CD99 may be correlated with a poor prognosis of the PETs.Conclusion This study confirms that the expression of CD99 is significantly correlated with the behavior of PETs.CD99 loss/low expression is associated with malignant progression and a poor prognosis of the PETs.It may prove to be an independent prognostic predictor of PETs.更多还原