【摘要】 报告1例颗粒状角化不全。患者女,25岁,右侧腹股沟红斑、斑丘疹伴痒10余年。体检:右侧腹股沟及阴阜右外侧可见10 cm×5 cm大小红斑;红斑基础上有绿豆至黄豆大小暗红色至紫红色丘疹,部分融合成斑块,部分区域可见轻度糜烂及痂屑;其余间擦部位未见相似皮损。皮损组织病理检查:表皮呈银屑病样增生,角化过度,灶状角化不全,角化不全内包含嗜碱性透明颗粒,其下颗粒层仍然存在,部分细胞胞质空泡化,真皮浅层血管周围少了淋巴组织细胞浸润,PAS染色阴性。根据临床及皮肤组织病理,诊断为颗粒状角化不全。更多还原

【Abstract】 A case of granular parakeratosis(GP) was reported.A 25-year-old woman presented with pruritic erythema and maculopapules in the right groin for about ten years.Physical examination showed an erythematous patch sized about 10 cm×5 cm in the right inguinal fold and right outboard of the pubes,on which there were dark-red to purple-red,bean-like papules,with some coalescing into plaques.Mild erosion and crusts were observed on part of the lesions.No similar lesions were detected on any other intertriginous regions.Histopathological analysis of lesions revealed psoriasiform hyperplasia of epidermis,a thick hyperkeratotic and parakeratotic horny layer with numerous retained basophilic keratohyalin granules,and preservation of the granular layer with some cytoplasmic vacuolated cells.Mild infiltrates of lymphocytes and histocytes was seen around vessels in the superficial dermis.The PAS staining yield negative result.The diagnosis of granular parakeratosis was made based on the clinical manifestations and histopathology.更多还原