【摘要】 目的探讨解除颈动脉狭窄对慢性低灌注大鼠认知功能损伤的影响及其可能机制。方法选择雄性SD大鼠30只,将制模成功大鼠12只随机分为狭窄组和狭窄解除组,每组6只。另选6只大鼠为假手术组。采用分光光度法测定超氧化物歧化酶(SOD)活性和丙二醛的含量。结果与假手术组比较,狭窄组大鼠SOD活性明显下降,丙二醛的含量明显升高,差异有统计学意义(P<0.01);与狭窄组比较,狭窄解除组大鼠SOD活性明显升高,丙二醛含量明显下降,差异有统计学意义(P<0.01)。结论氧化损伤参与了重度颈动脉狭窄所致认知功能障碍的作用机制;且解除颈动脉狭窄改善认知功能障碍的作用机制可能与改善脑血流、抗氧化作用有关。更多还原

【Abstract】 Objective To investigate the influence of relieving carotid stenosis on cognitive function of rats with chronic cerebral hypoperfusion injury and its possible mechanism.Methods Thirty male SD rats were selected,12 model rats were randomly divided into stenosis group and stenosisrelieving group of 6 rats each.Other 6 rats served as sham-operated group.Spectrophotometry was used to determine superoxide dismutase(SOD) activity and malondialdehyde(MDA) content. Results Compared with the sham group,the SOD activity was significantly decreased and MDA content significantly increased in stenosis group,the differences were statistically significant(P< 0.01).Compared with stenosis group,the activity of SOD significantly increased and MDA concentration significantly decreased in stenosis-relieving group(P<0.01).Conclusion Oxidative damage caused by severe carotid artery stenosis participates in the mechanism of cognitive impairment; and the mechanism of improving cognitive impairment by relieving stenosis may be associated with improving cerebral blood flow and antioxidative effects.更多还原