【摘要】 研究聚乙烯吡咯烷酮-阿霉素纳米颗粒(PVP-ADM-NP)的制备优化工艺。以聚乙烯吡咯烷酮为载体材料,以阿霉素为模型药物,采用溶剂去除法制备PVP-ADM-NP,对其制备工艺进行优化,并采用扫描电镜及激光粒度仪分别考察优化条件下纳米颗粒的形态、粒径分布。结果表明,激光粒度仪显示优化工艺条件下,纳米颗粒粒径在38～75nm,平均粒径54.4nm;PVP-ADM-NP在扫描电镜下呈现良好的圆整度,分布均匀同激光粒度仪结果相吻合。更多还原

【Abstract】 Doxorubicin-loaded nanoparticles using doxorubicin as model drug and polyvinylpyrrolidone as matrix material were prepared by the solvent-removable process.The property of the nanoparticles was characterized by Scanning Electron Microscopy(SEM) and Laser Light Scattering technique(LLS) respectively.LLS showed that the optimal prepared nanoparticles possessed an average size of 54.4nm and a narrow size distribution in 38～75nm,which was consistent with the results obtained by SEM.更多还原