【摘要】 目的探讨奈达铂联合5-Fu方案（NF方案）与超液化碘油乳剂治疗Ⅲ期肝细胞癌的疗效及安全性。方法 161例Ⅲ期肝细胞癌患者,用NF方案与超液化碘油乳剂化疗栓塞治疗。治疗方案为奈达铂100mg·m^-2行肝动脉灌注,结合5-Fu 1000mg·m^-2和超液化碘油5～30mL混合成乳剂栓塞。参照WHO抗癌药物毒性分级标准观察毒性反应,Child-Pugh分级观察肝脏损害,随访患者生存期。结果 161例患者,血液学毒性表现为骨髓抑制作用,中性粒细胞计数下降:Ⅰ度39.8%,Ⅱ度29.8%,Ⅲ～Ⅳ度17.4%。恶心呕吐:Ⅱ～Ⅲ度96.8%。肝脏Child-Pugh分级:术后32例由A级升至B级,4例由A级升至C级,9例由B级升至C级。肾毒性方面未见尿素氮（BUN）和血清肌酐（Cr）值升高。随访161例患者的生存期为5～35个月,中位值20个月。结论 NF方案联合超液化碘油乳剂化疗栓塞治疗Ⅲ期肝细胞癌是安全有效的,并且能改善病人的生活质量。更多还原

【Abstract】 Objective To evaluate the efficiency and safety of nedaplatin and 5-Fu in the treatment of stageⅢhepatocellular carcinoma（HCC）.Method 161 patients with HCC received trans-arterial chemoembolization（TACE）.The intra-arterial strategy consisited of nedaplatin(100 mg·m^-2),5-Fu (1000 mg·m^-2) and ultra-lipoidal iodide oil（5～30 mL）.The toxicity and hepatic injury were evaluated according to WHO anticancer drug toxicity criterion and Child-Pugh classification criterion,respectively.The survival time was also recorded during follow-up.Results In 161 patients,the toxicity of blood was bone marrow restrain.Decrease in white blood cell count was recorded:gradeⅠin 39.8%of patients,gradeⅡin 29.8%and gradeⅢ～Ⅳin 17.4%.GradeⅡ～Ⅲnausea and vomiting developed in 96.8%of the patients. Hepatic injury became aggravated in 32 patients from A to B class,in 4 patients from A to C class,and in 9 patients from B to C class according to Child-Pugh classification criterion.The median survival time was 20 months with a range from 5 to 35 months.Conclusion Nedaplatin combined with 5-Fu and ultralipoidal iodide oil emulsion was safe and efficient in the treatment of patients with stageⅢhepatocellular carcinoma.Trans-arterial chemoembolization（TACE） can improve life quality.更多还原