【摘要】 [目的]探讨肺癌发病的危险因素。[方法]采用病例对照研究方法,收集病例和对照各781例,进行流行病学调查及实验检测分析。[结果]室内烹调油烟、装修后刺激性气味、居室通风不良、吸烟、常自己炒菜可增加肺癌风险;而烧菜油温不过热和BRCA2基因rs144848 C等位基因具有保护作用。吸烟、室内烹调油烟和居住平房具有交互作用。[结论]肺癌与吸烟、环境污染有关,rs144848位点C等位基因可能具有保护作用。更多还原

【Abstract】 [Objective] To reveal risk factors of lung cancer.[Methods] A case-control study was designed with 781 lung cancer patients and 781 control subjects.Both epidemiological investigation and laboratory examination were performed in every subject.[Results] We revealed that smoke during cooking,irritant smell after decoration,insufficient ventilation,smoking and cooking presented increased risk of developing lung cancer.The low temperature of oil during cooking and rs144848 C allele were identified as protective factors.Smoking,smoke during cooking and living in bungalow showed a synergic effect.[Conclusion] The results suggest that smoking and air pollution are associated with lung caner.Rs144848 C allele may have protective effect on lung cancer.更多还原