【摘要】 目的观察孟鲁司特钠对婴幼儿毛细支气管炎的临床疗效以及对反复喘息的预防效果。方法将232例年龄为6～12个月的毛细支气管炎患儿随机分治疗组(n=120)和常规组(n=112)。治疗组在常规治疗的基础上加服孟鲁司特钠颗粒4mg,每晚1次,共3个月。观察各组患儿喘息、咳嗽及肺部哮鸣音的变化,记录喘息缓解、肺部哮鸣音消失及咳嗽消失所需时间;住院第1天及第7天查外周血中嗜酸性粒细胞计数;所有病例均随访1a,统计1a内喘息复发的人数。结果治疗组喘息缓解、肺部哮鸣音消失、咳嗽消失天数均少于常规组,差异有高度统计学意义(P<0.01),治疗组在住院第7天时血嗜酸性粒细胞计数较入院时降低,差异有高度统计学意义(P<0.01);常规组差异均无统计学意义(P>0.05)。治疗组1a内喘息复发作人数明显少于常规组,差异有高度统计学意义(P<0.01)。结论早期口服孟鲁司特钠治疗毛细支气管炎可以有效改善症状和体征,缩短病程;降低血嗜酸性粒细胞计数;减少婴幼儿喘息复发。更多还原

【Abstract】 AIM To observe the clinical effect of montelukast sodium on bronchiolitis and prevent recurrent wheezing in infants after brochiolitis.METHODS A total of 232 infants aged 6-12 months were randomly divided into 2 groups:the montelukast treated group(120 patients) and routine treated group(112 patients).The patients in montelukast treated group were treated by montelukast sodium,taking 4 mg once daily by routine complex treatment for 3 months.The clinical effects were evaluated in both groups after the treatment,before starting treatment and 7 days later. The clinical effects were observed.The statistical of recurrent wheezing in 2 group were discharged after 12 months.RESULTS The montelukast treated group was superior to the routine treated group in relieving asthma and shorting the wheezing sound disappearing cough(P < 0.01).Eosinophil counting lever decreased significantly in montelukast treated group after 7 days treatment(P < 0.01).There were significant decrements in wheezing infants in 12 months(P < 0.01).CONCLUSION Oral administration montelukast in early stage is effective,and it can reduce course of the illness and prevent recurrent asthmatic wheezing in infants after bronchiolitis.更多还原