【摘要】 目的:研究抑癌基因PTEN及凋亡抑制因子Survivin在卵巢上皮性癌中的表达及相关性。方法:应用免疫组织化学SP法,检测PTEN和Survivin蛋白在20例正常卵巢组织、21例良性上皮性卵巢肿瘤和38例卵巢上皮性癌中的表达。结果:PTEN在卵巢上皮性癌中的表达水平显著低于卵巢良性肿瘤及正常卵巢组织,差异有显著性(P<0.05);Survivin与PTEN相反,在卵巢上皮性癌中的表达显著高于良性卵巢肿瘤及正常卵巢组织(P<0.05)。Survivin与PTEN的表达呈负相关(r=-0.527,P=0.001)。两者的表达均与年龄及病理类型无关(P>0.05),而与临床分期、分化程度及是否转移相关(P<0.05)。结论:PTEN及Survivin蛋白的表达与卵巢上皮性癌的发生、发展有关;两者的联合检测有助于判断卵巢上皮性癌的恶性程度及预后。更多还原

【Abstract】 Objective: To investigate the expression and correlation of PTEN and survivin in ovarian epithelia carcinoma.Methods: The expression of PTEN and survivin in 38 cases of ovarian epithelial carcinoma,21 benign tumors and 20 normal ovarian tissue were determined by S-P immunohistochemical method.Results: The positive rate of PTEN in the ovarian carcer tissue was lower than in the normal and benign ocarian tumors(P<0.05).Survivin expression trend was opposite to that of PTEN.In ovarian epithelia carcinoma,negative correlation between expression of PTEN and survivin was abserved(r=-0.527,P=0.001).No different expression of PTEN and survivin among histological types or ages was found(P>0.05).The expression level of PTEN and survivin were associated with differentiation,clinic stage(P<0.05).Conclusions: PTEN and survivin may play an important role in the initation,development and prognosis of ovarian epithelia carcinoma and the combination of PTEN and survivin expression may be helpful in predicting the malignant degree and prognosis of ovarian epithelia cancer.更多还原