【摘要】 目的探讨表皮生长因子(EGF)和胃泌素(GAS)在胃癌组织中的表达,及其相互关系与意义。方法选取我院2003年1月～2009年12月经病理确诊的胃癌(GC)70例,慢性浅表性胃炎(CSG)25例,经过纳入标准及排除标准的筛选而作为研究对象。采用免疫组织化学Envision方法,检测EGF、GAS在各组胃黏膜组织中的表达情况。结果 GAS在CSG和GC中表达的阳性率分别为56.0%和84.3%,CSG组与GC组比较,差异有显著性(P<0.05);表皮生长因子(EGF)在CSG和GC中表达的阳性率分别为48.0%和97.1%,在GC中的表达显著高于CSG组(P<0.05)。结论 CSG中GAS呈低表达,幽门螺杆菌(Hp)感染则GAS表达增强:GC的GAS表达升高。在胃癌组织黏膜中,EGF表达增加;CSG中EGF呈低表达,Hp感染诱导EGF表达上调,GAS可能参与上调EGF的表达。更多还原

【Abstract】 Objective To investigate the expression and correlation of epidermal growth factor(EGF) and gastrin(GAS) expression in gastric cancer and their significance.Methods To select 70 cases gastric cancer(GC) tissue,25 cases normal gastric mucosal(CSG) tissues which were confirmed by pathologically during the period of January 2003 and December 2009 in our hospital were investigated.All samples were enrolled in this research according to the eligibility criteria.the samples were divided into different groups and compared.The expression of EGF,GAS were evaluated with immunohistochemical method of envision.Results Positive rates of gastrin expression in CSG and GC were 56.0% and 84.3%,respectively,and there were significant differences between GC and CSG.Gastrin expression was significantly higher in CSG with helicobacter pylori(Hp) infection than those without Hp infection(P<0.05).Positive rates of EGF expression in CSG,and GC were 48.0% and 97.1% respectively,and there were significant differences between GC and CSG.EGF expression was significantly higher in CSG with Hp infection than without Hp infection(P<0,05).Conclusion Gastrin expression is decreased,but Hp infection up-regulates the expression of gastrin in CSG,gastrin expression increases in GC.EGF expression has an increasing tendency in the gastric cancer.Hp infection induces up-regulation of EGF expression,and gastrin may take part in up-regulation of EGF expression in GC.更多还原