【摘要】 目的:研究自然人群中颈-股脉搏波传导速度(C-FPWV)与心脑血管事件和全因死亡的关系。方法:在包头医学院第二附属医院体检科连续收集556例体检者的基本资料,并对体检者进行C-FPWV测定,平均随访5年,观察其终点事件的发生率。结果:动脉硬化组的心血管事件发生率(16.1%∶6.4%)和全因病死率(7.7%∶2.4%)均高于正常组,且差异有统计学意义。在重度动脉硬化组、轻度动脉硬化组和正常组的心血管事件发生率(分别为22.7%,10.7%和6.4%)和全因病死率(分别为10.5%,5.6%和2.4%)差异有显著统计学意义(P<0.001)。经Logistic回归分析后,重度动脉硬化组发生心脑血管事件的OR为4.609(95%CI:2.288～9.285),全因死亡的OR为4.763(95%CI:1.653～13.719)。轻度动脉硬化组发生心脑血管事件的OR为1.717(95%CI:0.822～3.586),全因死亡的OR为2.320(95%CI:0.777～6.920)。分别作C-FPWV与心脑血管事件和全因死亡的ROC曲线,得到预测心脑血管事件和全因死亡的最佳临界点分别为10.85m/s和11.05m/s。结论:C-FPWV可以独立预测心脑血管事件的发病和死亡风险。更多还原

【Abstract】 Objective:To study the relationship between carotid-femoral pulse wave velocity(carotid-femoral pulse wave velocity,C-FPWV) of natural populations and cardio-cerebrovascular events and all cause mortality.Method:556 cases of continuous basic health examination data were enrolled from the Second Affiliated Hospital of Baotou Medical College,and the subjects were measured for C-FPWV to observe the incidence of end-point events after an average of 5 years follow-up.Result:Atherosclerosis group,the incidence of cardiovascular events(16.1% vs 6.4%) and all-cause mortality(7.7% vs 2.4%) were higher than normal group,and it was statistically significant.In the severe atherosclerosis,mild atherosclerosis group and the normal group,the incidence of cardiovascular events(22.7%,10.7% and 6.4%) and all-cause mortality(10.5%,5.6% and 2.4%) differences were significant(P<0.001).Logistic regression analysis showed that occurrence of cardio-cerebrovascular events odds ratio(OR) in severe atherosclerosis group(C-FPWV≥12 m/s) was 4.609(95%CI: 2.288-9.285),all cause mortality ORwas 4.763(95%CI: 1.653-13.719).Occurrence of cardiovascular events OR inMild atherosclerosis group(9 m/s<C-FPWV<12 m/s) was 1.717(95%CI: 0.822-3.586),and all cause mortality ORwas 2.320(95%CI: 0.777-6.920).From ROC curves plotted between the C-FPWV and cardio-cerebrovascular events by all-cause death,the best cut-off point for predicting cardio-cerebrovascular events and all-cause death were 10.85 m/s and 11.05 m/s respectively.Conclusion:C-FPWV could independently predict the incidence of cardio-cerebrovascular events and death risk.更多还原