【摘要】 目的:观察经皮冠状动脉介入(PCI)治疗所致外周血妊娠相关血浆蛋白A(cPAPP-A)水平的变化。方法:应用ELISA法检测20例冠心病(CAD,CAD组)患者PCI术前及术后20h、30h的cPAPP-A水平,另23例冠状动脉造影(CAG)正常的人群(对照组)为对照。结果:CAD组术后20hcPAPP-A水平(6.61±2.56)μg/L,与术前[(3.82±1.41)μg/L、对照组(3.72±1.52)μg/L]比较,均差异有统计学意义;术后30h(4.92±1.35)μg/L,显著下降,但仍显著高于术前。结论:PCI引发斑块破裂可导cPAPP-A水平升高。更多还原

【Abstract】 Objective:To observe the change of pregnency associated plasma protein A(cPAPP-A) levels following coronary plaque rupture induced by percutaneous coronary stent implantation(PCI),to explore the causality between the change of cPAPP-A levels and plaque rupture. Method:The cPAPP-A levels of 23 cases without CAD and 20 patients with CAD before PCI and 20 h,30 h after PCI were measured and analysed. Result:cPAPP-A levels of CAD group were significantly increased at 20 h([6.61±2.56]μg/L) after PCI(P<0.01),but were significantly decreased at 30 h([4.92±1.35]μg/L) after PCI(P<0.05),still were significantly increased than that([3.82±1.41]μg/L) before PCI(P<0.05). Conclusion:Coronary plaques rupture induced by PCI could lead to higher cPAPP-A levels,early detection of cPAPP-A is possibly helpful to early diagnosis of acute coronary syndrome.更多还原