【摘要】 目的:观察冠状动脉支架置入术(CSI)对急性冠状动脉综合征(ACS)患者血浆非对称性二甲基精氨酸(ADMA)水平的影响。方法:入选ACS患者(ACS组)81例(包括急性心肌梗死30例,不稳定型心绞痛51例),其中仅行药物治疗30例(非CSI亚组);行急诊CSI治疗51例(CSI亚组);另选取经冠状动脉造影排除ACS的人群54例作为对照组。采用高效液相色谱法测定冠状动脉治疗(造影)前,后1 h、1周、1个月时血浆ADMA水平,比较各组患者不同时期血浆ADMA水平的变化。结果:①ACS组血浆ADMA水平显著高于对照组(P<0.05);②CSI亚组患者血浆ADMA水平迅速且持续的降低(F=11.8,P<0.0001);非CSI亚组血浆ADMA水平缓慢下降(F=16.3,P=0.000);③对照组在冠状动脉造影后血浆ADMA水平升高,但总体水平低于ACS患者(F=7.4,P=0.000)。结论:CSI不仅不会使血浆ADMA水平增加,还能进一步降低其水平,其影响血浆AD-MA水平的机制与单纯冠状动脉造影对血浆ADMA水平的影响机制可能不同。更多还原

【Abstract】 Objective:To study the effects of coronary stent implantation(CSI) on the plasma levels of asymmetrical dimethylarginine(ADMA) in patients with acute coronary syndrome(ACS).Method:Concentration of plasma ADMA were measured by HPLC method in 81 ACS patients before,and 1 h,7 days,and 30 days after CSI or conservative treatment,and in 54 patients without ACS who underwent angiography alone(control group).Result:①The level of ADMA was increased significantly in ACS patients compared with control group(P<0.05).②In patients with ACS,CSI markedly decrease the plasma level of ADMA(F=11.8,P<0.0001).③Coronary angiography alone results in an increase of ADMA(F=7.4,P=0.000).Conclusion:CSI treatment in ACS can decrease the plasma level of cardiovascular risk factor ADMA,it may play an important role in improving the prognosis of ACS patients.The CSI effect on ADMA level cannot be explained by unspecific effects of the Coronary angiography.更多还原