【摘要】 目的:评价拉西地平和贝那普利治疗高龄老年高血压的疗效。方法:选择2006-01-01至2009-12-31在我院门诊治疗的高龄老年高血压患者188例,随机分为拉西地平组和贝那普利组,观察2组的降压效果、并发症和停药率。结果:2组平均观察2.5年,拉西地平组患者血压平均下降25.75/13.54mmHg(1mmHg=0.133kPa),贝那普利组患者血压平均下降24.11/13.48mmHg,与治疗前相比,差异有统计学意义(P<0.05)。2组降压的总有效率分别为82.98%和85.11%,2组的降压效果相当(P>0.05)。拉西地平组主要事件发生率为10.64%,贝那普利组主要事件发生率为8.51%,2组差异无统计学意义(P>0.05)。拉西地平组的次要事件发生率、总体事件发生率和停药率分别为22.34%、32.98%和5.32%,而贝那普利组的次要事件发生率、总体事件发生率和停药率发生率分别为40.43%、48.94%和14.89%,2组差异有统计学意义(P<0.01,P<0.05)。结论:拉西地平和贝那普利均能有效治疗高龄老年高血压,但前者的次要事件明显少于后者,拉西地平的依从性明显好于贝那普利。更多还原

【Abstract】 Objective:Try to evaluate the effect of lacidipine and benazepril treatments on aged hypertensive patients.Method:188 aged hypertensive out-patients from January 1,2006 to December 31,2009 in our hospital were randomly divided into lacidipine group and benazepril group,and the two drugs’ effects,complications,and discontinuation rates were observed subsequently.Result:In 2.5 year period’s observation,blood pressure was decreased by an average of 25.75/13.54 mmHg in Lacidipine group,while in benazepril group,blood pressure was reduced by an average of 24.11/13.48 mmHg,both compared with before treatment,remarkablely,the difference was statistically significant(P<0.05).Total effective rates of that two groups were 82.98% and 85.11% respectively,and both shared almost same antihypertensive effects(P>0.05).And more,Lacidipine group main event rate was 10.64%,in contrast,Benazepril group main event rate was 8.51%,and the two groups showed no significant difference(P>0.05).Further,the secondary incident rate,the overall event rate and the discontinuation rate of lacidipine group were 22.34%,32.98% and 5.32% respectively,while in benazepril group,those rates respectively were 40.43%,48.94% and 14.89%,thus this two groups showed no significant difference(P<0.01,P<0.05).Conclusion:lacidipine and benazepril both could treat aged hypertensive patients effectively,but secondary incident rate of lacidipine group was lower than benazepril group.The compliance of lacidipine was significantly better than that of benazepril.更多还原