【摘要】 目的探讨MRI形态学表现与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体(CerbB-2)和增殖细胞核抗原Ki-67的相关性。方法对18例共20个癌灶(其中两例双乳均见癌灶)原发性乳腺癌患者术前行MRI检查,分析其MRI形态学表现。术后采用ElivisionTMplus免疫组化法对ER、PR、CerbB-2和Ki-67进行测定。结果 1)乳腺癌MRI形态学指标:18例20个癌灶中有边缘毛刺者14个(70%),有边缘强化征象12个(60%)有分叶征10个(50%);2)MRI形态学与免疫组化指标相关性:癌肿分叶征与Ki-67之间呈正相关(P=0.035);分叶征与ER、PR、CerbB-2无相关性;边缘毛刺及边缘强化与癌细胞ER、PR、CerbB-2及Ki-67无相关性。结论分叶征与Ki-67有显著相关性,表明具有分叶征的乳腺癌有更高的增殖活性;边缘强化及边缘毛刺对提示肿块的侵袭性、恶性程度及预后无关,对指导肿瘤的治疗无明确意义。更多还原

【Abstract】 Objective To investigate the correlation of morphological MRI features with the expression of estrogen receptor(ER),progesterone receptor(PR),CerbB-2 and Ki-67 in breast cancer.Methods MRI was performed in 18 patients with primary breast cancer(20 foci,2 patients had foci in bilateral breasts),and morphological features of breast cancer were analyzed.The expression of ER,PR,CerbB-2 and Ki-67 in breast cancer was measured by ElivisionTMplus immunohistochemistry after operation.Results Among the 18 patients,MRI showed peculated margin in 14(70%),ring-enhancement in 12(60%) and lobulation in 10(50%).The lobulation was positively correlated with Ki-67 expression(P=0.035),but had no correlation with the expression of ER,PR and CerbB-2.Ring-enhancement and speculated margin did not show correlation with the expression of ER,PR,CerbB-2 and Ki-67.Conclusion There is a positive correlation between the lobulation and Ki-67 expression,suggesting that breast cancer with lobulation has a higher proliferative activity.Ring-enhancement and speculated margin have no correlation with the invasiveness,degree of malignancy and prognosis of breast cancer,suggesting that ring-enhancement and speculated margin have no definite significance in guiding the therapy of breast cancer.更多还原