【摘要】 目的:研究血浆抵抗素水平与重型脑外伤预后的相关性。方法:取80例重型脑外伤患者在入院时及入院后第1、2、3、5、7天静脉血,另取80例体检健康者静脉血做对照。用ELISA法测定血浆抵抗素浓度,分析血浆抵抗素水平与格拉斯哥(GCS)评分及死亡的相关性,以及抵抗素水平对重型脑外伤患者1个月内死亡的预测特异度和敏感度。结果:脑外伤后第1、2、3、5、7天血浆抵抗素水平明显增高。入院时血浆抵抗素水平增高是脑外伤1个月内死亡的危险因素(P=0.042),与入院时GCS评分呈显著负相关(P<0.001),对脑外伤后患者1个月内死亡有显著预测价值(P<0.001)。结论:脑外伤后血浆抵抗素水平显著增高,可作为重型脑外伤患者预后判断的重要指标。更多还原

【Abstract】 Aim: To determine the correlation of plasma resistin level with disease outcome in patients with serious traumatic brain injury (TBI). Methods: Venous blood was obtained from 80 cases on admission at day 1, 2, 3, 5, and 7 after TBI. Plasma resistin concentration was measured by enzyme-linked immunosorbent assay. Venous blood from 80 healthy people was also measured as control. Results: After TBI, plasma resistin level increased significantly. Plasma resistin level on admission was an independent predictor for 1-month mortality (P=0.042), and was negatively associated with Glasgow coma scale score (P<0.001), and predicted 1-month mortality of patients with the high value. Conclusion: Plasma resistin level increased significantly after TBI, maybe as an important predictor for clinical outcome.更多还原