【摘要】 目的:研究便携式加速度记录定量化评价帕金森病(PD)患者运动障碍程度的特异性。方法:61例PD患者根据国际治疗指南接受常规治疗,于治疗前与治疗后(30～60d后)将便携式加速度记录仪佩戴于患者利手侧手腕连续记录6d。同时利用帕金森病统一评分量表(UPDRS)评价治疗前后PD患者的临床评分;同时解析加速度记录仪记录的身体活动数据,评价PD患者治疗前后的幂型自相关指数(PLE)的变化,分析UPDRS评分与PLE的相关性。结果:与治疗前比较,治疗后PD患者的UPDRS评分以及PLE值均显著改善(P<0.05),PLE改善率与UPDRS评分以及运动障碍部分(PartⅢ)评分的改善率呈直线相关(分别r=0.794和0.823,P<0.01);结论:利用PLE解析加速度记录仪所记录的身体运动可以用于客观定量化评价PD运动障碍的程度,有较高的特异性,可作为PD患者门诊疗效评价的工具。更多还原

【Abstract】 Aim:To evaluate a specific,objective scale representing disease severity for appropriate management of patients with Parkinson’s disease (PD). Methods:61 patients with PD were treated according to the international medication guiding principle for PD treatment. Every patient wore a actigraph for 6 days before and 30-60 days after the treatment separately. The power-law exponent (PLE) recorded were analyzed,which corresponded to the levels of patients physical activity. Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS) for PD. The changes of PLE were evaluated before and after the treatment and their relations with the improvements of UPDRS scores were analyzed. Results:Both the UPDRS scores and the PLE values for the PD patients were improved obviously after the drug administration,which yielded a liner correlation coefficient of 0.794 and 0.823 between the improvements of total UPDRS scores and the PLE values,the UPDRS Part III and the PLE values respectively (P<0.01).更多还原