【摘要】 目的:探讨Mina53（Myc—induced nuclear antigen 53）在肾细胞癌中的表达及意义。方法:利用免疫组化SP法测定96例经HE病理确诊RCC组织和20例癌旁组织中Mina53的表达,并分析其结果与病理分级及l临床分期之间的关系。结果:Mina53在癌旁组织和Ⅰ期、Ⅱ期RCC组织中不表达或低表达,在Ⅲ期、Ⅳ期RCC组织中高表达,在Ⅳ期与Ⅰ、Ⅱ、Ⅲ期间的表达差异有统计学意义（P<0.01）;在不同的病理分级G₃与G₂,G₃与G₁中表达差异有统计学意义（P<0.05）。结论:Mina53在RCC组织中的表达与临床病理分期、分级有关,随着病理分级和临床分期的升高而增强,Mina53的高表达与肾细胞癌的临床进展有关。更多还原

【Abstract】 Objective:To study the expression of Mina53 in renal cell carcinoma(RCC) and its role in carcinogenesis and tumor progression.Methods:The expression of Mina53 was determined in RCC(n =96) and normal renal tissues(n = 20) by immunohistochemistry.and the relationship between the expression of Mina53 with clini-copathological characteristics was analyzed.Results:Mina53 was negatively expressed in all normal renal tissues, and weakly positive staining in TNM stageⅠandⅡ.while was significantly higher inⅢandⅣ(P <0.01),higher in histological grade 3 than grade 1 and grade 2(P <0.05).Conclusions:Mina53 was overexpressed in advanced RCC.showing a significant correlation with clinicopathological stage and histological grade.it maybe play an important role in the carcinogenesis and progression of RCC.更多还原