【摘要】 探讨肾上腺钙化性纤维性肿瘤(CFT)的临床表现、病理学变化及鉴别诊断方法,并讨论其生物学行为。方法:回顾性分析1例肾上腺CFT患者的临床资料,并结合国内外文献对本病的临床表现、病理学特点、鉴别诊断及治疗方法和预后进行讨论。结果:患者出现腰痛及反复肉眼血尿;病理形态学的主要特点为肿瘤境界清楚,细胞成分稀少,肿瘤主要由胶原化纤维构成,可见散在钙化或砂粒体及小团淋巴细胞、浆细胞浸润。免疫组织化学显示梭形细胞vimentin阳性,desmin、ALK、CD34、MSA、S-100均阴性。结论:肾上腺CFT需与其它肾上腺梭形细胞肿瘤相鉴别。本瘤生物学行为良性,局部肿瘤切除即可治愈。更多还原

【Abstract】 Objective:To study the clinical manifestations and pathologic changes of calcifying fibrous tumor (CFT) of adrenal gland,and discuss its differential diagnosis and biologic behaviour.Methods:Report a new case of CFT of adrenal gland review the previous literatures to analyse the clinical,imagining and pathological characteristics, differential diagnoses,treatment and prognosis of CFT of adrenal gland.Results:CFT is an uncommon benign tumor.Solid organ samples,adrenal gland included,more likely occur in adults.Their pathological changes included dense hyalinized fibrous tissue containing bland spindle-shaped cells,calcifications,and lymphoplasmacytic infiltrate. Immunostaining showed the spindle cells in CFT positive for vimentin,negative for desmin,ALK,CD34, MSA,S-100.Conclusions:CFP of adrenal gland needs to be differential diagnosed to other spindle cell tumors which could occur in this site.Given its benign biologic behaviour,complete local excision appears to be curative.更多还原