【摘要】 目的:比较奥氮平和利培酮治疗老年期谵妄的疗效和安全性。方法:将50例老年期谵妄患者随机分成奥氮平治疗组(n=25),利培酮治疗组(n=25),疗程2周。治疗前后以谵妄评定方法中文修订版(CAM-CR)及临床疗效总评量表-病情严重程度(CGI-SI)评定疗效;以治疗中出现的症状量表(TESS)评定药物不良反应。结果:奥氮平组和利培酮组显效率分别为64.0%和68.0%(P>0.05)。两组CGI-SI总分治疗后均较治疗前明显降低(t=5.19、6.95,P均<0.01);两组间比较,差异无统计学意义(P>0.05)。利培酮组不良反应明显高于奥氮平组(χ2=5.88,P<0.05)。结论:奥氮平和利培酮治疗老年期谵妄疗效相当,不良反应轻。更多还原

【Abstract】 Objective:To compare the efficacy and safety of olanzapine and risperidone in the treatment of senile delirium. Method:Fifty patients with senile delirium were randomly divided into olanzapine treatment group(n=25) and risperidone treatment group(n=25) .They were prospectively observed and assessed with the Chinese revision of confusion assessment method(CAM-CR) ,clinical global impression severity scale(CGI-SI) and treatment emergent symptom scales(TESS) . Results:The effective rate of olanzapine treatment group and risperidone treatment group were 64.0% and 68.0% respectively(P>0.05) .CGI-SI total scores of olanzapine treatmeng group and that of risperidone treatmen group were both reduced significantly after treatment(t=5.19,6.95;P<0.01) ,CGI-SI scores of two groups after treatment had no significant difference(P>0.05) .The total incidence rate of side effects in the risperidone group was significantly higher than that in olanzapine group(χ2=5.88,P<0.05) . Conclusion:Olanzapine and risperidone have similar effects in treating senile delirium,and has fewer side effects.更多还原