【摘要】 目的:系统评价手术治疗对难治性强迫症的临床疗效和不良反应。方法:通过检索国内文献数据库2010年7月前已发表的关于手术治疗难治性强迫症的临床研究进行系统评价。结果:共纳入8项临床研究(共209例患者)。对患者手术前及手术后6个月、1年和2年的Yale-Brown强迫症状量表(Y-BOCS)数据进行Meta分析,结果显示术后6个月差异均值(MeanDifferenceIVFixed,95%CI)=13.31;术后1年随访,MDIV(95%CI)=9.68;术后2年随访,MDIV(95%CI)=13.41。在不良反应方面,手术后并发有尿失禁、记忆减退、运动障碍、人格改变、多睡、头痛及颅内血肿,多在术后2周恢复正常。结论:手术治疗可显著改善强迫症患者症状;手术治疗的不良反应较少,安全性高。更多还原

【Abstract】 Objective:To systematically evaluate the clinical efficacy and side effects of surgical treatment used in obsessive-compulsive disorder(OCD).Method:By searching the database of domestic literature,the paper about surgical treatment used in obsessive-compulsive disorder published before July 2010,and then systematic analysis of the data.Results:A total of eight clinical studies(included 209 patients).Meta-analysis the Yale-Brown obsessive compulsive scale(Y-BOCS) data of the cases followed up in 6 months,1 year and 2 years,showed that after 6 months:MD IV(95%CI)=13.31;after 1 year:MD IV(95%CI)=9.68,after 2 years:MD IV(95%CI)=13.41.The side effects:urinary incontinence,memory impairment,dyskinesia,fever,personality changes,sleep too much,headache,intracranial hematoma.Most complications were back to normal in 2 weeks.Conclusion:Surgical treatment can significantly improve symptoms in patients with obsessive-compulsive disorder;surgical treatment fewer side effects and safe.更多还原