Nucleotide(s) analogues have been widely used in the treatment of chronic hepatitis B.It is important to deal with the relapsed patients treated with an initial nucleotide(s) analogues therapy properly,and grasp of re-treatment program reasonably.Patients treated with nucleotide(s) analogues can be divided into two categories: being treated and relapsed after treatment.The first group of patients should be managed by the concept of the road map meanwhile the latter should be depending on the initial treatme...