【摘要】 目的探讨蒙特利尔认知功能评估量表(MoCA,中文版)和事件相关电位-P300在血管性认知功能障碍中的应用比较。方法将137例脑血管病患者进行简易精神状态检查量表(MMSE)测试后分为无认知功能障碍(NCI)组、无痴呆的轻度血管性认知功能障碍(VCIND)组和血管性痴呆(VD)组,分别进行P300和MoCA测试。结果①随认知障碍程度的加深,MoCA评分逐渐降低,P300潜伏期延长,波幅降低(P<0.01)。②在诊断VD中,以MMSE为金标准,MoCA敏感度较高(敏感度100%,特异度54.0%,准确度70.8%),P300潜伏期与其类似(敏感度100%,特异度58.6%,准确度73.7%);P300波幅采取两种分界值,敏感度分别为82.0%和44.0%,特异度80.5%和97.7%,准确度81.0%和78.1%。结论 MoCA及P300均随认知障碍程度而改变,可作为认知障碍的监测指标;MoCA和P300潜伏期对轻度血管性认知功能障碍更敏感;P300波幅敏感度低,不能作为判断血管性认知功能障碍认知功能的依据。更多还原

【Abstract】 Objective To compare Montreal Cognitive Assessment Scale(MoCA)(Chinese version) and event-related potential-P300 in vascular cognitive impairment.Methods 137 patients with cerebrovascular diseases tested by MMSE were divided into non-cognitive impairment(NCI) group,vascular cognitive impairment no dementia(VCIND) group and vascular dementia(VD) group.All the three groups were tested by event-related potentials-P300 and MoCA.Results ①With the progress of cognitive impairment,MoCA score gradually decreased,latency of P300 extended and amplitude decreased.②In the diagnosis of VD,with MMSE as the gold standard,MoCA had higher sensitivity(sensitivity 100%,specificity 54.0%,accuracy 70.8%),P300-latency was similar with it(sensitivity 100%,specificity 58.6%,accuracy 73.7%),P300-amplitude adopted two boundary values(sensitivity 82.0% and 44.0%,specificity 80.46% and 97.7%,accuracy 81.0% and 78.1%).Conclusion P300 and MoCA change with the degree of cognitive impairment can be detected as indicators of cognitive impairment;MoCA and P300-latency for mild vascular cognitive impairment are more sensitive,and because of low sensitivity,P300-amplitude can not serve as cognitive function diagnosis of vascular cognitive impairment.更多还原