【摘要】 心血管系统中主动脉粥样硬化斑块的钙化主要发生在动脉内膜,能够预测心血管系统疾病的风险性和死亡率,对钙化物的矿物组成及形成机制的分析有望为主动脉粥样硬化的发生发展过程提供辅助信息。本文以心血管主动脉粥样硬化斑块中的钙化物为研究对象,采用偏光显微镜、扫描电子显微镜及X射线能谱仪、微区X射线衍射、透射电子显微镜以及傅里叶变换红外光谱仪等矿物学研究手段,对原位和分离的钙化物的矿物形态、成分、结构等进行了较为系统的观察测试。研究结果表明,主动脉粥样硬化斑块钙化物的主要成分为纳米尺寸的粒状、针状及柱状的B型碳羟磷灰石,并与低n(Ca)/n(P)的磷酸钙矿物共存。钙化初期是沉淀在胶原纤维上的低n(Ca)/n(P)磷酸钙矿物小球,在钙化发展过程中,胶原纤维随之钙化并不断富集,形成最终的块状钙化。更多还原

【Abstract】 The calcification in aortic atherosclerotic plaque of cardiovascular system usually occurs in the arterial intima,which is a strong predictor of the cardiovascular risk and mortality,and the analysis of mineral composition and mechanism may support the research on the origin and development of atherosclerosis.This paper focuses on the calcification in aortic atherosclerotic plaque,using mineralogical methods,such as POM,SEM,EDAX,μ-XRD,TEM and FTIR,to investigate the mineral morphology,composition and structure of both original and separated calcification.This research suggests that the calcification is composed of nano-size granular,needlelike and short prismatic type B carbonate-hydroxyapatite,together with calcium phosphates of relatively low values of Ca/P(At%).Furthermore,the early stage of calcification is mineralized balls precipitating on the collagen fibers,which results in the calcification of collagen fibers,concentration and ultimately large calcification deposits.更多还原