【摘要】 目的:研究口腔黏液表皮样癌组织中RKIP和抑癌基因NPRL2的表达,探讨其表达与口腔黏液表皮样癌各临床病理因素之间的关系。方法:应用免疫组织化学染色方法检测48例口腔黏液表皮样癌组织和13例正常组织中RKIP和NPRL2的表达,并对其与临床病理特征的关系进行统计学分析。结果:RKIP和NPRL2均表达于黏液表皮样癌细胞的胞浆和部分胞膜。黏液表皮样癌组织与正常组织中RKIP和NPRL2高表达的阳性率分别为52.08%,92.31%和47.92%,100.00%,黏液表皮样癌组织与两者比较有显著性差异(P<0.05)。结论:RKIP和NPRL2可能参与了黏液表皮样癌的发生、发展过程。更多还原

【Abstract】 Objective: To explore the expression and clinical pathology significance of tumour suppressor genes RKIP and NPRL2 in mucoepidermoid carcinoma(MEC).Methods: RKIP and NPRL2 proteins’ levels were determined with immunohistochemistry in 48 cases of MEC and 13 cases of normal tissue.The correlation between these two proteins and MEC pathology was detected,too.Results: RKIP and NPRL2 mainly located in cellular membrane and plasma of MEC.Percentage of RKIP and NPRL2 positive tissue of MEC and normal tissue were 51.9 %,92.2% and 53.9%,93.4% respectively.Expression of RKIP and NPRL2 proteins were markedly lower in MEC than that in normal tissue(P<0.05).Conclusion: There might be a involvement of RKIP and NPRL2 in occurrence and development of MEC.更多还原