【摘要】 目的:研究血管内皮生长因子(vascular endothelial growth factor,VEGF)在涎腺腺样囊性癌中的表达,探讨其与临床病理因素的关系。方法:采用SABC免疫组织化学染色方法检测32例涎腺腺样囊性癌(salivary ade-noid eystic carcinoma,SACC)中VEGF的表达和病灶微血管密度(microvessel density,MVD)记数,采用SPSS13.0软件行统计分析。结果:62.5%SACC组织呈VEGF阳性表达。VEGF表达阳性的SACC组织MVD显著高于VEGF表达阴性者(P<0.05)。VEGF表达与肿瘤病理类型、淋巴结转移、肿瘤部位及临床分期密切相关。结论:VEGF是SACC主要的新生血管诱导因子之一,可促进SACC的血管生成,VEGF可做为SACC预后的一个有效指标,用于识别高危转移和不良预后者。更多还原

【Abstract】 Objective: To evaluate the clinical significance of vascular endothelial growth factor(VEGF) expression in salivary adenoid cystic carcinoma(SACC).Methods: Immunohistochemical staining(SP) was used to quantify VEGF and CD34 expression in specimens from 32 patients with SACC.SPSS13.0 statistical software was used.Results: VEGF expression was observed in 20 of the patients(62.5%).The microvessel count was significantly higher(P<0.05) in the SACC with VEGF expression than in the SACC without it.In the clinicopathologic factors,pathology category(P<0.05),lymph node metastasis(P<0.05),tumor position(P<0.01),clinicopathologic stage(P<0.05) were significantly correlated with VEGF positive expression.Conclusion: This study indicates that VEGF expression is associated with angiogenesis,VEGF is one of the main angiogenic factors for SACC.Quantification of VEGF in SACC may provide a valuable marker for a prognosis of patients with SACC.更多还原