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三七原人参三醇型总皂苷和人参三醇的4个衍生物的合成研究

Synthesis of Derivatives of Panaxatriol and Protopanaxatriol from Panax Notoginseng

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【Author】 HUANG Zi-ying1),ZHAO Sheng-ding1),ZOU Cheng1),ZHAO Qing2),WANG Ji-liang1),HU Jian-lin1)(1)Pharmaceutical School & Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming Yunnan 650500;2)Chinese Material Medical College of Yunnan University of TCM,Kunming Yunnan 650200,China)

【机构】昆明医学院药学院暨云南省天然药物药理重点实验室；云南中医学院中药学院；

【摘要】目的研究三七中原人参三醇型总皂苷及人参三醇为原料的衍生物合成.方法分别将原人参三醇和人参三醇经Jones氧化、NaBH4还原和PCC氧化、NaBH4还原.结果制备了10个衍生物,其中4个化合物为新化合物.结论这4个新化合物简明易得,为得到大量衍生物并进行活性筛选奠定了基础.更多还原

【Abstract】 Objective To synthesize the derivatives of panaxatriol and Protopanaxatriol from Panax notoginseng.Method Protopanaxatriol was oxidated with Jones and obtained with NaBH4 and Panaxatriol was oxidated with PCC and obtained with NaBH4.Result Ten derivatives were obtained and four of them were new compounds.Conclusion Four new compounds are easy to get and make the foundation for activity screening of a large number of derivatives.更多还原

【关键词】三七；三七总皂苷；原人参三醇；人参三醇；
【Key words】 Panax notoginseng； Panax notoginseng saponins； Protopanaxatriol； Panaxatriol；

【基金】国家自然科学基金资助项目(81160388);云南省药学高校重点实验室基金资助项目(2010ZL002)

【文献出处】昆明医学院学报 ,Journal of Kunming Medical University , 编辑部邮箱 ,2011年11期

【分类号】S567.51
【被引频次】8
【下载频次】291

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