【摘要】 目的比较托烷司琼与昂丹司琼预防全麻妇科手术后恶心呕吐的效果.方法选择135例择期全麻下行腹式子宫全切除术患者(ASAⅠ～Ⅱ级),随机分为3组(n=45),分别于术毕拔管前缓慢静注生理盐水4 mL,托烷司琼4 mg/mL,昂丹司琼8 mg/4 mL,观察术后24 h内恶心呕吐情况并作比较.结果托烷司琼和昂丹司琼抑制术后24 h恶心呕吐的发生率分别为73%和60%,显著高于对照组33%(P<0.05).与对照组相比,托烷司琼和昂丹司琼都可有效降低恶心呕吐的发生(P<0.05),但托烷司琼组和昂丹司琼组之间差异无统计学意义(P>0.05).结论术后拔管前静注托烷司琼4 mg或昂丹司琼8 mg均能有效预防或减轻术后恶心呕吐.更多还原

【Abstract】 Objective To compare the efficacy of tropisetron and ondansetron in the prevention of postoperative nausea and vomiting after gynecological surgery under general anesthesia.Methods Forty-five ASAⅠ～Ⅱ patients undergoing abdominal hysterectomy under general anesthesia were randomly divided into three groups(n=45).At the end of the surgery,the patients were given intravenously tropisetron 4 mg,ondansetron 8 mg,or normal saline respectively.The episodes of nausea and vomiting were observed for 24 h after operation.Results The effective rate of tropisetron and ondansetron to inhibit the incidence of postoperative nausea and vomiting was 73% and 60% respectively.Both of them significantly reduced the degree of postoperative nausea and vomiting(P<0.05).There was no significant difference between tropisetron and ondansetron in efficacy(P>0.05).Conclusion Intravenous injection of tropisetron 4 mg or ondansetron 8 mg at the end of the surgery can significantly reduce the incidence of postoperative nausea and vomiting in patients undergoing abdominal hysterectomy under general anesthesia.更多还原