【摘要】 目的研究雷公藤多苷的化学成分。方法采用硅胶,Sephadex LH-20等柱色谱方法进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定。结果分离得到10个化合物,分别鉴定为wilforlide B(1),wilforol A(2),demethylregelin(3),3-hydroxy-2-oxo-D:A-friedoolean-3-en-29-oic acid(4),3β,22β-dihydroxy-urs-12-en-30-oic acid(5),orthosphenic acid(6),wilforol B(7),regelindiol B(8),tripterygicacid A(9),tripfordine A(10)。结论化合物5,8为首次从该植物中分离得到,其中5为首次从自然界中分离得到。更多还原

【Abstract】 Objective To study the chemical constituents of the total glucosides of Tripterygium wilfordill Hook.F.Methods The compounds were separated and purified by column chromatography and their structures were elucidated by spectroscopic methods.Results Ten compounds were isolated and identified as wilforlide B(1),wilforol A(2),demethylregelin(3),3-hydroxy-2-oxo-D:A-friedoolean-3-en-29-oic acid(4),3β,22β-dihydroxy-urs-12-en-30-oic acid(5),orthosphenic acid(6),wilforol B(7),regelindiol B(8),tripterygic acid A(9),tripfordine A(10).Conclusion Compound 5,8 was obtained from this plant for the first time,and compound 5 was reported as natural product firstly.更多还原