Objective To study the clinical characteristics of idiopathic hypogonadotropic hypogonadism(IHH) and its related gene mutations in females.Methods Clinical data and laboratory findings about 4 IHH patients were analyzed.Sequences of the GnRHR,KAL1 and FGFR1 genes in 3 patients and controls were detected by PCR.Results No secondary sex characters were found in the 4 female IHH patients who had a normal karyotype,underdeveloped sexual phenotype,low gonadotropic hormones and estradiol levels.Brain MRI showed n...