Objective To study the role of tumor necrosis factor-alpha(TNF-α) and nitric oxide synthetase(NOS) in cardiac function of rats with sepsis.Methods A sepsis model of rats was established.The hemodynamics was monitored,the levels of TNF-α and nitric oxide(NO) were measured,and the activity of NOS was assayed.Results The levels of TNF-α and NO in cardiac muscle tissue reached their peaks 2h after the model was established,which were in accordance with the time of impaired cardiac function.The expression of cNO...
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