【摘要】 目的探讨Ki-67和p53蛋白在肾癌中的表达和临床意义。方法应用免疫组化方法对66例肾癌组织进行Ki-67和p53蛋白检测。结果在肾癌组织中Ki-67和p53蛋白表达阳性率分别为62.1%和39.4%。Ki-67表达与肾细胞癌分级、分期相关(P<0.05),与肾癌的病理类型无关(P>0.05)。p53表达与肾癌的病理类型、分级、分期无关(P>0.05)。结论 Ki-67表达水平随着肾癌组织的病理分级和临床分期的增高而增高,与肿瘤的生物学行为有一定关系。而p53表达在肾癌生物学行为不具有重要意义。更多还原

【Abstract】 Objective To study the expression of Ki-67 and p53 in renal cell carcinoma(RCC) and its clinical significance.Methods The protein of Ki-67 and p53 was examined in 66 cases of RCC immunohistochemistry.Results The positive rate of expression of Ki-67 and p53 were 62.1% and 39.4% in RCC.The positive rate of expression of Ki-67 in RCC were significantly related to the clinical stage or clinical grade(P<0.05),but not related to the type of the renal cell carcinoma(P>0.05).The positive rate of expression of p53 in RCC were not related to the clinical stage,the clinical grade and the type of the renal cell carcinoma(P>0.05).Conclusion The expression level of Ki-67 increased markedly with the clinical stage or clinical grade of RCC and it was related to the biological behavior of neoplasms.But p53 plays an unimportant role in RCC.更多还原