【摘要】 目的:为探讨中药联合苯那普利治疗慢性肾脏病(CKD)的疗效。方法:将60例CKD(3期)患者随机分为中药(简称1组)、西药(简称2组)、中西治疗组(简称3组),每组20例;采用双盲法给予中药、苯那普利、中药联合苯那普利治疗,疗程24周;对患者在投药初始以及12、24周的实验室指标及中医症状积分进行对照分析。结果:中医症状积分:在24周,各组较治疗前均下降(P<0.01),其中,3组下降较1、2组差异有统计学意义(P<0.05)。24h尿蛋白定量:在12周,2、3组下降较1组差异有统计学意义(P<0.05);在24周,3组下降较1组差异有统计学意义(P<0.05)。血红蛋白(Hb):在24周,2、3组较治疗前明显下降(P<0.05)。血清白蛋白(Alb):在24周,2、3组较治疗前明显升高(P<0.05),而2组较3组升高明显(P<0.05)。血尿素氮(BUN):在24周,2组较治疗前明显升高(P<0.05)。血肌酐(Scr):在24周,2组较1组及3组升高明显(P<0.05)。肾小球滤过率(eGFR):在12周,2组较1组明显降低(P<0.01)。总疗效比较:在24周,依据中医证候疗效标准判定,3组有效率为89%、1组为65%、2组为40%,组间比较(P<0.01);根据西医疗效标准判定,3组有效率为94%、2组为85%、1组为75%,组间比较(P<0.05)。结论:中药联合苯那普利较单纯中药或苯那普利能更好的改善CKD的临床症状,降低尿蛋白,延缓肾功能减退。更多还原

【Abstract】 Objective:To observe the effect of integrated Chinese medicine and Benazepril on chronic kidney disease (CKD).Methods:60 patients of CKD(3 th stage ) were divided into Chinese medicine group (1 group),Benazepril group (2 group) and integrated group (3 group) randomly,with 20 patients in each group.All the patients were given Chinese medicine,Benazepril,integrated Chinese medicine and Benazepril double-blindly for 24 weeks.The scores of TCM syndrome and laboratory indices were compared at 0 th,12th,24th weeks.Results:At 24 th,scores of TCM syndromes in three groups decreased significantly comparing to 0 th (P<0.01),more obviously in 3 group (P<0.05).At 12 th,24 h urinary protein in 2 group and 3 group decreased significantly than 1 group(P<0.05),and at 24 th lower than 1group in 3 group(P<0.05).At 12 th Hb decreased significantly in 2,3 group than baseline(P<0.05).At 24 th,Alb in 2,3 group increased significantly to baseline(P<0.05),and higher than 1 group in 2 group(P<0.05).At 24 th,BUN in 2 group increased significantly than baseline,and Scr increased significantly than 1 and 3 group(P<0.05).At 12 th,eGFR declined significantly in 2 group than 1 group(P<0.01).At 24 th,According to the criterion of Chinese medicine syndrome therapeutical effect,the effective rate in 3,1and 2 group was 89%、65%、40% respectively(P<0.01).However,the effective rate to Western medicines standards was 94% in 3 group,85% in2 group and 75% in 1 group(P<0.05).Conclusion:The integrated Chinese medicine and Benazepril was better than Chinese medicine or benazepril alone to improve clinical syndrome,to reduce urine protein and to delay the progression of renal function.更多还原