Bile acid transporter,which is abundant on the hepatic cell surface,provides a promising way in accessing the hepatic cell targeted drug delivery.In the present study,poly-[3α-(4-vinylbenzonate)-7α,12α-dihydroxy-5β-cholan-24-oic acid](PVBCA),an amphiphilic polymer with bile acid structure in the side-chain,was designed and synthesized.PVBCA coated PLGA nanoparticles with a diameter of 350 nm were prepared by emulsion-solvent evaporation method and PVBCA assembled on the nanoparticle surface due to its amphi...
【基金】
国家自然科学基金(20806043);
教育部高校博士点基金(200800031011)~~
【更新日期】
2011-12-14
【分类号】
R944.9
【正文快照】
靶向给药系统(targeted drug delivery system,TDDS)因能显著提高药物利用率并降低药物毒副作用而受到普遍关注,特别在癌症的治疗方面发展迅速并有着广阔的前景[1-2]。利用配体分子修饰载药纳米粒表面,基于靶向细胞表面受体与配体特异性识别的介导作用,可高效地实现药物的靶向?
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