【摘要】 目的探讨携带放射性¹²⁵Ⅰ子食管支架治疗高龄中、晚期食管癌的初步疗效。方法总结2009年9月-2010年12月新乡医学院第一附属医院食管支架治疗的43例中、晚期食管癌老年患者,根据是否自愿接受¹²⁵Ⅰ粒子支架分为A、B两组。A组为¹²⁵Ⅰ粒子支架治疗组,18例;B组为普通支架治疗对照组,25例。两组患者的年龄、病变长度、狭窄程度以及分期差异无统计学意义（患者均未做放疗及化疗）。术中、术后观察、统计并随访支架置入成功率、吞咽困难缓解率、并发症发生率及生存期。结果 A、B两组支架置入成功率均为100%,短期吞咽困难缓解率100%。A组的平均生存期为9.8个月,B组的平均生存期为4.8个月,两组间差异有统计学意义（P<0.01）。支架置入后疼痛、食管再狭窄等并发症发生率分别为27.8%及28.0%,两组间差异无统计学意义（P>0.05）。结论根据短期临床观察,125I粒子食管支架治疗中晚期食管癌能明显延长患者生存期。临床初步应用是安全、可行、有效的。治疗中、晚期食管癌放射性¹²⁵Ⅰ粒子支架优于传统支架。更多还原

【Abstract】 Objective To investigate the therapeutic effect of the implantation of esophageal stent with radioactive ¹²⁵Ⅰ particles in treating advanced esophageal carcinomas in aged patients.Methods During the period from Sep.2009 to Dec.2010,implantation of esophageal stent was used to treat 43 aged patients with advanced esophageal cancer.Based on the patient’s free will,the patients were divided into study group（n = 18） receiving stent with ¹²⁵Ⅰ particles and control group（n = 25） receiving ordinary stent without ¹²⁵Ⅰ particles.No significant difference in the age,the lesion length,the degree of stenosis and the disease stage existed between the study group and the control group.The technical success rate,the remission rate of dysphagia,the occurrence of complications and the mean survival time were calculated and analyzed.The results were compared between the two groups.Results The technical success rate was 100% in both groups.The short-term remission rate of dysphagia was also 100% in both groups.The mean survival time in the study group and in the control group was 9.8 months and 4.8 months respectively,the difference between the two groups was statistically significant（P < 0.01）.No significant difference in the occurrence of postoperative pain and esophageal restenosis existed between the two groups（P > 0.05）.Conclusion This results of study indicate that for the treatment of advanced esophageal carcinomas the implantation of esophageal stent with radioactive ¹²⁵Ⅰ particles can surely and markedly prolong the patient’s survival time and relive the symptom of dysphagia.This technique is safe,feasible and effective in clinical practice.The use of the stent with radioactive ¹²⁵Ⅰ particles is superior to the use of the traditional stent in treating patients with advanced esophageal cancer.更多还原