【摘要】 目的研究电刺激大脑岛叶对大鼠心率变异(Heart Rate Variability,HRV)的影响。方法检测麻醉状态下大鼠的心电图(ECG),将动物分成未处理组、假手术组、500以及1000μA点刺激组,对各组大鼠进行ECG数据的采集,对各组大鼠心率变异的频域指标进行分析。结果 HRV各参数值发生变化,表现为心动周期的标准差(standard deviation of R-R intervals,SDNN)和相邻正常心动周期差值的均方根(the root mean square successive differences in milliseconds,RMSSD)下降,而LF/HF(Low frequency/high frequency,低频/高频)升高,与假手术对照组之间比较,差异有显著意义,且1000μA电刺激比500μA时HRV参数下降幅度更大。结论 LF/HF的明显升高提示电刺激大脑岛叶使交感和迷走神经功能失调而发生HRV改变。更多还原

【Abstract】 Objective Objective To study the effect of electric stimulating to insular on heart rate variability (HRV) of rat.Methods Rats were divided into untreated,precondition,500μA electric stimulating groups.Electric cardiography (ECG),HRV,SDNN(standard deviation of R-R intervals),RMSSD (the root mean square successive differences in milliseconds),TP(total power)and LF/HF(low frequency/high frequency)were determined.Results The values of SDNN,RMSSD and TP were lower distinctly in 500μA than in untreated and precondition groups.But the value of LF/HF was higher in 500μA.Conclusion The elevation of LF/HF by electric stimulating to insular of rat indicates that decrease of HRV might be related to the functional disorder of sympathesis and vagus nerve.更多还原