【摘要】 目的研究红霉素对离体家兔窦房结自律性的影响。方法用细胞内微电极技术记录并观察红霉素对家兔窦房结细胞慢反应动作电位的作用。结果红霉素可使家兔窦房结细胞自律性兴奋频率(SHR)、慢反应动作电位4期自动除极速率(SDR)和0期除极最大速率(Vmax)明显减小,且效应具有剂量依赖性。0.3 mmol/L的红霉素使SHR从对照组的120.0±5.8 beats/min减少到99.2±4.3 beats/min,减少17.2%(F=6.37,P<0.05),SDR和Vmax分别减少24.9%和13.1%(F=10.84,P<0.05和F=4.51,P<0.05)。结论红霉素可能主要通过减慢4期自动除极速率(SDR)而减慢窦房结的自律性。更多还原

【Abstract】 Objective To explore the effect of erythromycin on autorhythmicity of the isolated rabbit sinus node.Methods Intracellular microelectrode technique was used to investigate the effect of erythromycin on slow action potential of rabbit sinus node cell.Results Erythromycin reduced spontaneous heart rate(SHR),spontaneous depolarization rate of phase 4(SDR)and maximal upstroke velocity of action potential(Vmax) in a dose-dependent manner.Conclusion Erythromycin may slow autorhythmicity of sinus node cell by reducing spontaneous depolarization rate of phase 4(SDR).更多还原