【摘要】 利用激光光镊拉曼光谱系统,测定健康者红细胞(RBC)和心律失常患者红细胞的拉曼光谱,对健康者红细胞与心律失常患者红细胞的拉曼光谱进行了比较,发现心律失常患者红细胞的部分谱线整体强度有所减弱,部分谱线发生了频移;另外,低强度He-Ne激光对心律失常患者红细胞也存在一定的影响。根据拉曼光谱差异性,进一步探讨其红细胞内容物的改变情况及其变化机理,了解心律失常患者红细胞中分子结构、构象、组成的变化,从分子水平探讨心律失常患者的发病机制。更多还原

【Abstract】 Using optical tweezers Raman spectroscopy system to test and compare the Raman spectra of red blood cells (RBCs) between normal human and arrhythmia patients,we find that the overall intensity of some spectral lines of arrhythmia patients becomes weaker,several lines have a displacement,and the low intensity He-Ne laser irradiation has a certain impact on arrhythmia patients red blood cells.According to the diversity of Raman spectra,we further research the changes of the contents in red blood cells and its variation mechanism,and understand the changes of red blood cells′ molecular structure,conformation and composition in different types of arrhythmia disease,and also investigate the pathogenesis of arrhythmia disease by the molecular level.更多还原