【摘要】 目的探讨我国长寿地区中老年人群传统心血管疾病(cardiovascular disease,CVD)危险因素与慢性肾脏病(chronic kidney disease,CKD)的关系。方法选取7个中国长寿之乡的所有百岁老人,以及在该地区按百岁老人编码尾数随机选取的40~、60~、80~和90~岁人群为研究对象,进行CKD及相关危险因素的问卷调查、体格检查和血尿检测,肾功能评价采用MDRD方程估计的肾小球滤过率(eGFR),并将人群按eGFR水平分为3组,采用方差分析进行组间均值比较,组间率比较采用χ2检验,以有无CKD为因变量,进行单因素和多因素Logistic回归分析。结果随着eGFR水平下降,CVD危险因素检出率增加;单因素分析显示,年龄、女性、高血压、高甘油三酯(TG)、高低密度脂蛋白胆固醇(LDLC)是CKD的危险因素;多因素Logistic分析显示,年龄、女性、高血压、高TG是CKD的危险因素。结论长寿地区中老年人群CVD危险因素随eGFR水平下降检出率增高,年龄、女性、高血压、高TG是CKD的危险因素。更多还原

【Abstract】 Objective To explore the correlation between risk factors of cardiovascular disease(CVD) and chronic kidney disease(CKD) in longevity areas in China.Methods All centenarians in 7 longevity areas were selected,as well as randomly selected aged 40~,60~,80~ and 90~ population in the same 7 areas,CKD and associated risk factors of questionnaire survey,physical examination and biochemical tests were conducted.Glomemlar filtration rate(GFR) using the Modification of Diet in Renal Disease equation was estimated.All participants were divided into three groups by eGFR level.Univariate and multivariate Logistic regression models were used to identify the associated risk factors.Results Exposure rate of CVD risk factors increased along with the decrease of eGFR level.Data from univariate Logistic regression analysis showed that age,female,high blood pressure,high TG,high LDLC were the risk factors of CKD.Results from multiple Logistic regression indicated that age,female,high blood pressure,high TG appeared to be independent risk factors of CKD.Conclusions Exposure rate of CVD risk factors increased along with the decrease of eGFR level,while age,female,high blood pressure,high level of TG were independent risk factors of CKD.更多还原