【摘要】 目的探讨早期干预治疗对新生儿缺氧缺血性脑病(HIE)预后和NBNA评分的影响。方法选择许昌市中心医院2007年2月至2010年12月收治的40例中重度HIE患儿随机分为干预组及对照组各20例,对照组给予常规治疗,如吸氧、保暖、控制脑水肿、降低颅内压、营养脑细胞等,干预组在常规治疗的基础上加用纳洛酮,7～14d为1个疗程。比较两组的临床疗效及神经行为NBNA评分。结果干预组总有效率为85%(17/20),对照组总有效率为70%(14/20),两组比较差异有统计学意义(P<0.05)。干预组的临床症状及体征的恢复也明显优于对照组,差异有统计学意义(P<0.05)。两组NBNA评分干预治疗1～3d比较差异无统计学意义(P>0.05);干预治疗7～10d差异有统计学意义(P<0.05)。结论新生儿缺氧缺血性脑病早期干预治疗可以明显提高HIE患儿的临床疗效,有效地控制HIE患儿的临床症状及体征,明显提高NBNA评分及改善患儿的预后,降低了死亡率,值得临床推广应用。更多还原

【Abstract】 Objective To investigate the early intervention on neonatal hypoxic ischemic encephalopathy(HIE) prognosis and NBNA score.Methods A hospital in February 2007~December 2010 40 patients were admitted with moderate to severe HIE were randomly divided into intervention group and control group each 20 patients,the control group was given conventional treatment,such as oxygen,warmth,control brain edema and reduce intracranial pressure,nutrition,and other brain cells,the intervention group based on the conventional treatment use naloxone,7 to 14 days for a course of treatment.Compare the clinical efficacy of the two groups and neurobehavioral NBNA score.Results The intervention group,the total effective rate was 85%(17/20),the control group the total effective rate was 70%(14/20),the difference was statistically significant(P<0.05).Intervention group,clinical symptoms and signs of recovery are significantly better than the control group,the difference was statistically significant(P<0.05).NBNA score intervention groups 1 to 3 days the difference was not statistically significant(P>0.05);Intervention for 7 to 10 days significantly(P<0.05).Conclusions Neonatal hypoxic ischemic encephalopathy early intervention can significantly improve the clinical efficacy in children with HIE,HIE patients effectively control the clinical symptoms and signs markedly improved NBNA score and improve the prognosis of patients,reducing the death rate,worthy of clinical application.更多还原