【摘要】 2,3,5-三氯吡啶在相转移催化剂4-二甲氨基-N-苄基氯化吡啶鎓盐催化下,环丁砜溶剂中与KF反应,合成标题化合物。当催化剂的用量与2,3,5-三氯吡啶的物质的量比为1∶10,反应物2,3,5-三氯吡啶的用量与KF的物质的量之比为1∶4,180℃下反应4 h,标题化合物收率79.1%。更多还原

【Abstract】 2,3-Difluoro-5-chloropyridine was synthesized from 2,3,5-trichloropyridine and KF in sulfolane using 4-dimethylamino-N-benzyl pyridinium chloride as the catalyst.The optimum technological condition for synthesis of 2,3-difluoro-5-chloropyridine is shown as follows:The reaction was conducted at a ratio of catalyst versus 2,3,5-trichloro-pyridine of 1∶10,and a molar ratio of KF versus 2,3,5-trichoropyridine of 1∶4 at a reaction temperature of 180 ℃ for 4 h.The total product yield could reach 79.1%.更多还原