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4-氨基安替比林Schiff碱的合成及其抗O2-活性
Synthesis and Anti-O2- Activity of 4-Aminoantipyrine-Schiff Base
【摘要】 合成了未见报道乙二醛双缩4-氨基安替比林、丁二酮双缩4-氨基安替比林和其它Schiff碱。对这些化合物进行了元素分析、红外、紫外和核磁谱的表征。对化合物进行了抗超氧阴离子活性的研究。试验表明,这些化合物都有抗超氧阴离子活性。
【Abstract】 In the article,4-aminoantipyrine Schiff bases were synthesized.Among them,two compounds,glyoxal pairs of contraction 4-aminoantipyrine and 4-butanedione pairs of condensed with 4-aminoantipyrine have not reported in the literature yet.These compounds were characterized by elemental analysis,IR,UV and 1H NMR.Tests were conducted to the compounds on the resistance activity of superoxide anion.The experimental results showed that the compounds had high activity resistance of superoxide anion free radical.
【关键词】 Schiff碱;
合成;
超氧离子自由基;
清除;
【Key words】 Schiff base; synthesis; superoxide anion free radical; inhibition;
【Key words】 Schiff base; synthesis; superoxide anion free radical; inhibition;
【基金】 国家自然科学基金资助项目(NO.21001092);民族药资源化学国家民委-教育部重点实验室资助
- 【文献出处】 化学工业与工程 ,Chemical Industry and Engineering , 编辑部邮箱 ,2011年05期
- 【分类号】TQ463
- 【被引频次】5
- 【下载频次】110