【摘要】 本文以邻氯三氟甲苯为起始原料,经混酸硝化,催化氢化,与BTC在1,2-二氯乙烷和1,4-二氧六环的混合溶剂中回流制得4-氯-3-(三氟甲基)苯异氰酸酯(三步总收率87.4%),再与4-(4-氨基苯氧基))-2-(甲基氨甲酰基)吡啶缩合成脲,制得抗肿瘤药物索拉菲尼,总收率为:84.0%,纯度:99.1%。更多还原

【Abstract】 The target product was prepared from p-Chlorobenzotrifluoride(1),which was transformed into the corresponding isocyanate(4) by mixed acid nitration,catalytic hydrogenation,and refluxed with BTC in the solution of 1,2-dichloroethane and 1,4-dioxare(the total yield of three steps was 87.4%),then 4 reacted with 4-(4-aminophenoxy)-N-methyl-2-pyridinecarboxamide(5) to give the unsymmetrical diaryl urea sorafenib(6) as antitumor agent,the total yield was 84.0%,purity 99.1%.更多还原