【摘要】 目的:采用不同频率的脉冲电磁场干预骨保护素基因敲除小鼠骨质疏松模型,探讨脉冲电磁场治疗骨质疏松的适宜频率。方法:8周龄雌雄各半骨保护素基因敲除小鼠30只,随机分为A,B,C组,每组各10只,A组为对照组,不进行干预;B组小鼠每天在强度为4 mT,频率为8 Hz的磁场中照射治疗20 min,共30 d;C组小鼠每天在强度为4mT,频率为32 Hz的磁场中照射治疗20 min,共30 d。各组小鼠在治疗前及治疗30 d后用双能X线检测骨密度值。结果:治疗后B,C组骨密度值与A组比较差异有统计学意义(P<0.05);B,C组骨密度值比较差异无统计学意义(P>0.05)。结论:脉冲电磁场对骨保护素基因敲除小鼠骨质疏松有治疗效果,频率为8~32 Hz的磁场治疗疗效相同。更多还原

【Abstract】 Objective To study the optimal treatment frequency of pulsed electromagnetic fields for osteoporosis by intervening osteoprotegerin gene knockout osteoporosis mice with different frequency impulse electromagnetic fields.Methods Thirty osteoprotegerin knockout mice aged 8 weeks old were randomly divided into three groups,10 each.Group A did not receive pulsed electromagnetic fields treatment.Group B received pulsed electromagnetic fields treatment at 8 Hz frequency with 4.0 mT intensity,20 minutes daily,totally for 30 days.Group C received pulsed electromagnetic fields treatment at 32 Hz frequency with 4.0 mT intensity,20 minutes daily,totally for 30 days.Each group was measured bone density by dual energy X-ray absorptiometry before and after treatment.Results After treatment,the bone density in group B and C was different from that in group A(P<0.05),and there was no significant difference between group B and group C(P>0.05).Conclusion The pulsed electromagnetic fields treatment is effective for osteoprotegerin gene knockout osteoporosis mice,and the frequencies from 8 Hz to 32 Hz can get the same therapeutic effect.更多还原