【摘要】 目的:探讨扶正消瘤颗粒(TCM of Enhance Resistance for Slaking Neoplasm,TerSN)含药血清对乳腺癌多耐药细胞体外生长、增殖的影响。方法:通过血清药理学方法,制备不同浓度含药血清,作用于乳腺癌多耐药细胞,应用倒置相差显微镜观察细胞生长状况,血球计数法测定细胞生长曲线,MTT法检测细胞抑制率。结果:3组含药血清(1倍量、2倍量血清组与等效量血清组)对乳腺癌多耐药细胞增殖均有抑制作用,细胞抑制率分别达72.31%、72.45%、50.16%,差异有统计学意义(P<0.01),1倍量、2倍量血清组与等效量血清组相比,差异有统计学意义,P值分别为0.017和0.016(0.01<P<0.05)。结论:TerSN可通过抑制乳腺癌多耐药细胞增殖而增强化疗药物的疗效。更多还原

【Abstract】 Objective:To study the effect of herb serum to TCM of Enhance Resistance for Slaking Neoplasm(TerSN) on grow and proliferation of drug-resistant cells in breast cancer.Methods:With the methods of serum pharmacology,drug-resistant cells of breast cancer was treated by several doses contained-herb serum.The growth and proliferation was observed by Cell growth state,Blood count method and MTT assay;Results:The three groups(Double,Triple and The equivalent of blood drug concentration) of contained-herb serum could inhibit the growth of drug-resistant cells of breast cancer and there was a marked positive correlations between drug concentrations(P<0.01).There is statistical significance Among double(P=0.017) and triple(P=0.016) to ordinary doses(0.01<P<0.05),the inhibiting rate to cells get 72.31%、72.45%、50.16% respectively.Conclusion:The TersN can improve chemotherapy drug-sensitivity of drug-resistant cells,by inhibiting the growth of drug-resistant cells in breast cancer.更多还原