【摘要】 目的:探讨甲基丙二酸半胱氨酸在小儿早期VitB12缺乏症诊断中的作用。方法:维生素B12缺乏亚临床症状组50例、临床症状组50例及正常健康儿童50例,测定其红细胞平均体积(MCV),红细胞平均血红蛋白(MCH),血清维生素B12、尿中甲基丙二酸(MMA)及血清半胱氨酸(Hcy)浓度。结果:①临床症状组MCV(114.2±11.2)fl、MCH(32.1±2.7)pg较正常对照组MCV(89.4±3.5)fl、MCH(29.1±3.9)pg显著增高,差异有统计学意义(P<0.05)。亚临床症状组MCV(90.1±8.6)fl、MCH(28.9±2.6)pg较正常组MCV(89.4±3.5)fl、MCH(29.1±3.9)pg差异无统计学意义(P>0.05)。②临床症状组VitB12(126±74)pg/ml较正常对照组VitB12(512±78)pg/ml下降,差异有统计学意义(P<0.05),亚临床症状组VitB12(498±90)pg/ml较正常对照组VitB12(512±78)pg/ml稍下降,差异无统计学意义(P>0.05)。③亚临床症状组MMA(4.789±0.030)μg/mg肌酐Hcy(21.8±5.6)μmol/L临床症状组MMA(5.451±0.115)μg/mg肌酐Hcy(26.3±3.1)μmol/L均较正常对照组尿MMA(1.000±0.061)μg/mg肌酐及血清Hcy(10.6±5.3)μmol/L水平增高,差异有统计学意义(P<0.05)。结论:甲基丙二酸(MMA)及半胱氨酸(Hcy)水平测定可以作为维生素B12早期缺乏的敏感的指标。更多还原

【Abstract】 Objective:To study the effect of methylmalonic acid,homecysteine in early diagnosis of Vi tB12 deficiency children. Methods:Menstruate the concentrat ion of mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),mean c orpuscular hemoglobin(MCH),serum vitamin B12,urine methylmalonic acid(M MA) an d serum homocysteine(Hcy) of sub-clinical symptoms group of 50 patients with V itB12 deficiency,clinic group of 50 patients and control group of 50 norm al hea lthy children. Results:①Clinical group MCV(114.2±11.2) fl,MCH(32.1±2.7) pg were higher than control group MCV(89.4±3.5) fl,MCH(29.1±3.9) pg,the differences were significant(P<0.05).Sub-clinical symptoms group MCV(90.1±8.6) fl,MCH(28.9±2. 6) p g compared with normal group MCV(89.4±3.5) fl,MCH(29.1±3.9) pg,and the diff erence were not significant(P>0.05).②Clinic group VitB12(126±74) pg/ml compared with normal group showed decline,the differences were significant(P <0.05).Sub-clinic symptoms group VitB12(498±90) pg/ml had slightly decrea se than normal group VitB12(512±78) pg/ml,which did not show statistica lly si gnificant(P>0.05).③Sub-clinical symptoms group MMA(4.789±0.030) μg/mg c reatinine Hcy(21.8±5.6) μmol/L and clinical group MMA(5.451±0.115) μg/m g cre atinine Hcy(26.3±3.1) μmol/L compared with the normal control group MMA(1.000 ±0.061)μg/mg in urine,creatinine Hcy(10.6±5.3) μmol/L in serum,were signi ficantly higher,which had significant differences(P<0.05). Conclusion:The levels of methylmalonic acid(MMA) and homocysteine(Hcy) could be the sensi tive indicators of early VitB12 deficiency.更多还原