【摘要】 目的: 评价血清促卵泡生长素( FSH) 水平和雄激素( T) /促黄体生长素( LH) 比值 2 项检测指标联合在实施辅助生殖前对无精子症患者精子获得的预测作用。方法: 209 例已实施人类辅助生殖技术( ART) 的无精子症患者[病理诊断梗阻性无精子症( OA)138 例,非梗阻性无精子症( NOA) 71 例],回顾分析 OA 和 NOA 患者 FSH、LH、泌乳素( PRL)和 T 等激素水平和 T/LH 值的变化。比较指标联合( FSH 和 T/LH) 进行分型诊断与病理诊断结果之间的符合率差异,同时比较联合预测方法与 PESA/TESA 方法在预测精子获得上的一致性。结果: NOA 患者FSH、LH 值均高于 OA 患者( t = 15. 989 和 9. 074,P < 0. 001) ,而 T、T/LH 均低于 OA 患者( t = 4. 355 和 11. 092,P <0. 001) 。该诊断在的灵敏度为 97. 101% 、特异度为 90. 141% 、假阳性率为 2. 899% 和假阴性率为 9. 859% 。指标联合预测与 PESA/TESA 方法对区分 OA 和 NOA 结果一致( Kappa =0. 861,P <0. 001) 。结论: 血清 FSH 和 T/LH 比值2 项指标联合对无精子症患者进行分型诊断和预测患者有无精子准确、简便、易行。更多还原

【Abstract】 Aim:To evaluate the two test markers (serum FSH level and T/LH ratio) in predicting the sperm obtained rate before the implementation of assisted reproduction technology of azoospermia patients.Methods:A total of 209 azoospermia patients,who had been implemented ART,were divided into non-obstructive azoospermia (NOA) and obstructive azoospermia (OA) groups according to pathological diagnosis.Retrospective analysis of the levels of FSH,LH,PRL and T in each group.Results:The FSH,LH values in NOA group were significantly higher than that in OA group (t=15.989 and 9.074,P<0.001),T,T/LH ratio were significantly lower than that in OA group (t=4.355 and 11.092,P<0.001).There were no difference in sperm positive rates of two test markers prediction method and PESA/TESA method(Kappa=0.861,P<0.001).Conclusion:The two test markers of serum FSH,T/LH ratio are useful to predict the sperm obtaining of azoospermia.It is a more accurate,simple and easy method in assisted reproductive technology.更多还原