【摘要】 目的:检测胃癌、癌前病变及正常胃黏膜组织中核转录因子-κBP65(NF-κBP65)蛋白的表达情况,探讨其与胃癌发生发展的关系。方法:采用免疫组织化学法对20例正常胃黏膜、32例胃不典型增生及63例胃癌组织中的核转录因子-κBP65蛋白表达进行检测。结果:NF-κBP65蛋白在胃癌组织中的阳性率表达率(74.6%,47/63)与胃不典型增生组织(46.9%,15/32)及正常胃黏膜组织(5.0%,1/20)相比,差异有统计学意义(χ2=34.795,P<0.001)。胃癌组织中,NF-κBP65蛋白的阳性表达率与分化程度、浸润深度及有无淋巴结转移有关(χ2分别为6.426、6.682和5.416,P均<0.05)。结论:NF-κBP65不仅与胃癌的形成有关,且与胃癌的侵袭和转移有关。更多还原

【Abstract】 Aim:To investigate the expression of nuclear factor-κBP65(NF-κBP65)protein in human gastric carcinoma tissue,precarcinoma changes,and normal gastric mucous tissue.Methods:NF-κBP65 protein were detected in 20 cases of normal gastric mucous,32 cases of gastric dysplasia and 63 cases of gastric carcinoma tissue specimens using immunohistochemistry.Results:There was significant difference on positive expression rate of NF-κBP65 protein among gastric carcinoma(74.6%,47/63),gastric dysplasia(46.9%,15/32)and normal gastric mucous(5.0%,1/20)tissues(χ2=34.795,P<0.001).The expression of NF-κBP65 protein in gastric carcinoma tissue was associated with histological grade,invasive depth and lymph node metastasis(χ2=6.426,6.682,and 5.416,P<0.05).Conclusion:NF-κBP65 might be correlated with occurrence,invasion and metastasis of gastric carcinoma.更多还原