节点文献

112对同卵双胞胎贲门黏膜组织病理结果分析

Histopathological analyses on gastric cardia biopsy tissues from 112 pairs of momozygous twins

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【作者】王海艳；范宗民；王立东；周胜理；李吉林；焦新英；冯常炜；张延瑞；王晗晶；崔娟；宋爽；申芳芳；宋昕；郭涛；李江曼；

【Author】 WANG Haiyan1,2),FAN Zongmin2),WANG Lidong1,2),ZHOU Shengli1,2),LI Jilin3),JIAO Xinying3),FENG Changwei4),ZHANG Yanrui5),WANG Hanjing2),CUI Juan2),SONG Shuang2),SHEN Fangfang1),SONG Xin1,2),GUO Tao2),LI Jiangman2)1)Cancer Research Centre,Xinxiang Medical University,Xinxiang 450053 2)Henan Key Laboratory for Esophageal Cancer Research;the First Affiliated Hospital;College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450052 3)Department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456592 4)Department of Gastroenterology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014 5)Department of Gastroenterology,Henan Provincial People’s Hospital,Zhengzhou 450003

【机构】新乡医学院癌症研究中心；郑州大学河南省食管癌重点开放实验室；郑州大学第一附属医院郑州大学基础医学院；郑州大学第一附属医院；郑州大学基础医学院；林州市姚村食管癌医院病理科；郑州大学第二附属医院消化内科；河南省人民医院消化内科；

【摘要】目的:对比分析河南食管癌高发区同卵双胞胎贲门活检组织各级病变的病理诊断结果,探讨遗传和环境因素对贲门癌变的影响。方法:采用流行病学问卷调查、内镜检查和黏膜活检组织病理学检查,对食管癌高发区30岁以上同卵双胞胎进行现场普查。结果:112对双胞胎中,贲门腺癌6例,双发(两个成员均发病)贲门腺癌发生率0.9%(1/112),单发贲门腺癌发生率3.6%(4/112);双胞胎两个成员病理结果相同的有45对(40.2%),不同的有67对(59.8%)(Kappa=0.135,P=0.016)。结论:贲门腺癌是遗传和环境因素共同作用的结果,但环境因素在贲门腺癌的发生发展中可能起更重要的作用。更多还原

【Abstract】 Aim:To investigate the interactions between genetic and environmental factors on gastric cardia carcinogenesis by analyzing the pathological changes of gastric cardia biopsy tissues from momozygous twins at a high-incidence area for esophageal cancer in Henan.Methods:Monozygous twins with> 30 years old were invited to attend the mass survey with epidemiological questionnaire,endoscopic,biopsy and histopathological examinations.Results:Out of the 112 twins,6 cases of gastric cardia adenocarcinoma(GCA)were identified,and the incidence rate with consistent and inconsistent GCA was 0.9%(1/112)and 3.6%(4/112),respectively;two members of 45(40.2%)pairs of twins had the similar histopathological changes,and two members of 67(59.8%)pairs of twins were inconsistent in histopathological changes(Kappa=0.135,P=0.016).Conclusion:The present results demonstrate that GCA is the common sequence of environment and heredity,but environmental factor may have a larger contribution in gastric cardia carcinogenesis.更多还原

【关键词】同卵双胞胎；贲门腺癌；食管癌；
【Key words】 monozygotic twins； gastric cardia adenocarcinoma； esophageal cancer；

【基金】国家自然科学基金资助项目30971133

【文献出处】郑州大学学报(医学版) ,Journal of Zhengzhou University(Medical Sciences) , 编辑部邮箱 ,2011年01期

【分类号】R735.1
【被引频次】2
【下载频次】218

知网节下载

节点文献中：

本文链接的文献网络图示:

本文的引文网络

节点文献