【摘要】 目的:探讨脑立体定向术治疗难治性精神分裂症远期疗效及安全性。方法:采用脑立体定向术治疗难治性精神分裂症87例,术后随访2年以上;采用临床疗效总评定量表、阳性和阴性症状量表及精神症状简明量表对远期疗效进行评定,采用日常能力量表、社会功能缺陷筛选量表、临床疗效总评量表、韦氏成人智力量表及韦氏记忆量表评估手术安全性。结果:依据临床疗效总评定量表评定标准,87例患者中,显效40例,有效24例,稍有效12例,无变化7例,恶化0例,死亡1例,脱落3例。手术前后各量表评分差异均有统计学意义(P<0.01)。无严重并发症和后遗症。结论:脑立体定向术治疗难治性精神分裂症远期疗效稳定,安全性好;但术后应重视药物维持治疗和社会功能的恢复。更多还原

【Abstract】 Objective To determine the long-term effect and security of refractory schizophrenia with brain stereotaxis multi-target therapy technique. Methods A total of 87 patients with refractory schizophrenia were treated with brain stereotaxis multi-target therapy and were followed up over 2 years.The scores of Clinical Global Impression,Brief Psychiatric Rating Scale,Positive and Negative Symptom Scale,Wechsler Adult Intelligence Scale,Wechsler Memory Scale,Actives of Daily Living,and Social Disability Screening Schedule were compared before and after the operation. Results Of the 87 patients,40 obviously improved,24 improved,12 improved little,7 did not change.None grew worse,1 died,and 3 shed.There was a significant difference in the scales before and after the operation(P<0.01).No severe complications and sequelae occurred. Conclusion Stereotaxic multi-target therapy is effective and safe for refractory schizophrenia.After the operation,drug therapy should be maintained and recovery of social function is helpful.更多还原